Micinicate, RV-12128, Micivas
米西烟酯Chemical Name: Nicotinic acid,ester with cis-3,3,5-trimethylcyclohexyl (?mandelate; cis-3,3,5-Trimethylcyclohexyl dl-alpha-nicotinoyloxyphenylacetate; 3-Pyridinecarboxylic acid 2-oxo-1-phenyl-2-[(3,3,5-trimethylcyclohexyl)oxy]ethyl ester; Nicotinoyl cyclandelate
CAS No. 39537-99-0
项目整合开发状态: Launched-1987
项目研究机构: Ravizza (Originator)
合成路线:This compound has been obtained by two related ways:1) The reaction of the potassium salt of the nicotinic acid with oxalyl chloride in benzene gives the corresponding anhydride (II),which is condensed with 2-hydroxy-2-phenylacetic acid (III) in dioxane to yield the expected ester (IV).The reaction of (IV) with SOCl2 in dichloromethane affords 2-(nicotinoyloxy)-2-phenylacetyl chloride (V),which is finally esterified with the cyclohexanol (VI) in dichloromethane.2) By acylation of the 2-hydroxy-2-phenylacetic acid cis-3,3,5-trimethylcyclohexyl ester (VII) with nicotinoyl chloride (VIII) in pyridine.
📌 参考资料/链接：
参考文献标题:New process for preparing cis-3,3,5-trimethylcyclohexyl-D,L-alpha-(3-pyridinecarboxy)-phenylacetate
文献作者:Verga,A.(Ravizza SpA)
参考来源:EP 0157151
📄 详细内容
合成路线:This compound has been obtained by two related ways:1) The reaction of the potassium salt of the nicotinic acid with oxalyl chloride in benzene gives the corresponding anhydride (II),which is condensed with 2-hydroxy-2-phenylacetic acid (III) in dioxane to yield the expected ester (IV).The reaction of (IV) with SOCl2 in dichloromethane affords 2-(nicotinoyloxy)-2-phenylacetyl chloride (V),which is finally esterified with the cyclohexanol (VI) in dichloromethane.2) By acylation of the 2-hydroxy-2-phenylacetic acid cis-3,3,5-trimethylcyclohexyl ester (VII) with nicotinoyl chloride (VIII) in pyridine.
参考文献标题:Novel spasmolytic cpd.and process for its preparation
文献作者:Mauri,F.(Gaver SA)
参考来源:BE 0824034; DE 2461909; FR 2256757; JP 1975105670
产品链接: CAS No. 39537-99-0››