Mifobate, SR-202
米福贝特Chemical Name: Dimethyl alpha-(dimethoxyphosphinyl) p-chlorobenzyl phosphate; (4-Chlorophenyl)(dimethoxyphophinyl)methyl phosphoric acid dimethyl ester; Dimethyl (p-chloro-alpha-hydroxybenzyl)phosphonate,dimethyl phosphate
CAS No. 76541-72-5
项目整合开发状态: Phase II
项目研究机构: Ilex Oncology (Originator)
合成路线:The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II).Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g.,di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.
📌 参考资料/链接：
参考文献标题:SR-202
文献作者:Nguyen,M.L.; Bentzen,C.L.
参考来源:Drugs Fut 1982,7(4),271
📄 详细内容
合成路线:The reaction of chlorobenzoyl chloride (I) with trimethyl phosphite gives dimethyl p-chlorobenzoylphosphonate (II).Addition of dimethyl phosphite to (II) in the presence of 80% molar amount of an organic base (e.g.,di-n-butylamine) in diethyl ether or toluene at 0 C produces the final compound.
参考文献标题:
文献作者:Bentzen,C.L.; Nguyen,M.L.; Niesor,E.
参考来源:US 4309364
产品链接: CAS No. 76541-72-5››