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项目整合精选>>>Tetrofosmin [99m-Tc], Technetium (99mTc) tetrofosmin, PPN-1011, P-53(uncomplexed), Myoview
Tetrofosmin [99m-Tc], Technetium (99mTc) tetrofosmin, PPN-1011, P-53(uncomplexed), Myoview
替曲膦 Chemical Name: (OC-6-11)-Bis[6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane-P,P']dioxotechnetium(1+)-99Tc
CAS No. 127455-27-0, 127502-06-1 (ligand)
项目整合开发状态: Launched-1994
项目研究机构: Amersham (Originator)
合成路线:Tetrofosmin (III) was prepared by condensation of 1,2-diphosphinoethane (I) with ethyl vinyl ether (II) in the presence of AIBN.The title technetium complex was then prepared by treatment of a solution of sodium pertechnetate with a reducing agent in the presence of the bis-phosphine ligand (III).
📌 参考资料/链接：
参考文献标题:New cores for technetium radiopharmaceuticals
文献作者:Archer,C.M.; Dilworth,J.R.; Jobanputra,P.; Latham,I.A.; Thompson,R.M.(Amersham plc)
参考来源:JP 2002060397; WO 9103262
📄 详细内容
合成路线:Tetrofosmin (III) was prepared by condensation of 1,2-diphosphinoethane (I) with ethyl vinyl ether (II) in the presence of AIBN.The title technetium complex was then prepared by treatment of a solution of sodium pertechnetate with a reducing agent in the presence of the bis-phosphine ligand (III).
参考文献标题:Ligands and cationic complexes thereof with technetium-99m
文献作者:Kelly,J.D.; Chiu,K.W.; Latham,I.A.(Amersham plc)
参考来源:EP 0337654; JP 1997328495
合成路线:Tetrofosmin (III) was prepared by condensation of 1,2-diphosphinoethane (I) with ethyl vinyl ether (II) in the presence of AIBN.The title technetium complex was then prepared by treatment of a solution of sodium pertechnetate with a reducing agent in the presence of the bis-phosphine ligand (III).
参考文献标题:Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging
文献作者:Kelly,J.D.; Forster,A.M.; Higley,B.; Archer,C.M.; Booker,F.S.; Canning,L.R.; Chiu,K.W.; Edwards,B.; Gill,H.K.; McPartlin,M.; et al.
参考来源:J Nucl Med 1993,34(2),222
产品链接: CAS No. 127455-27-0›› 产品链接: CAS No.127502-06-1››