Tripropidil hydrochloride, MJ-12,880-1
替普地尔 Chemical Name: 1-[4-(Isopropylsulfanyl)phenoxy]-3-(octylamino)propan-2-ol hydrochloride
CAS No. 70895-39-5, 70895-45-3 (free base)
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The diazotation of 4-aminophenol (I) with NaNO2 and HCl followed by reaction with isopropylmercaptane (II) gives 4-(isopropylthio)phenol (III),which is condensed with epichlorohydrin (IV) by means of NaOH in water to yield 3-[4-(isopropylthio)phenoxy]-1,2-epoxypropane (V).Finally this compound is condensed with n-octylamine (VI) in refluxing ethanol and treated with HCl.
📌 参考资料/链接：
参考文献标题:
文献作者:Morrow,D.F.; Matier,W.L.
参考来源:BE 871143; DE 2844353; FR 2405932; GB 2006197; JP 7988232; NL 7810156; ZA 7805689
📄 详细内容
合成路线:The diazotation of 4-aminophenol (I) with NaNO2 and HCl followed by reaction with isopropylmercaptane (II) gives 4-(isopropylthio)phenol (III),which is condensed with epichlorohydrin (IV) by means of NaOH in water to yield 3-[4-(isopropylthio)phenoxy]-1,2-epoxypropane (V).Finally this compound is condensed with n-octylamine (VI) in refluxing ethanol and treated with HCl.
参考文献标题:Tipropidil Hydrochloride
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Thorpe,P.J.
参考来源:Drugs Fut 1982,7(4),277
产品链接: CAS No. 70895-39-5›› 产品链接: CAS No.70895-45-3››