Tropapride hydrochloride, MD-790501

曲帕必利Chemical Name: exo-2,3-Dimethoxy-N-(8-benzyl-8-azabicyclo[3.2.1]oct-3-yl)benzamide hydrochloride; N-(8-Benzyl-1alphaH,5alphaH-nortropan-3beta-yl)-o-veratramide hydrochloride
CAS No. 76352-13-1 (free base)
项目整合开发状态: Biological Testing
项目研究机构: Delalande (Originator)
合成路线:Treatment of 8-benzylnortropinone (I),obtained via Robinson-Sch鰌f cyclization with hydroxylamine gives the corresponding oxime (II),which is reduced with sodium in pentanol to yield the stereochemically pure 3beta-aminotropane derivative (III).This compound is condensed with 2,3-dimethoxybenzoic acid (IV) by means of ethyl chlorocarbonate and triethylamine.