Trecadrine, WAS-4304
曲卡君 Chemical Name: alpha(R)-[1(S)-[N-[2-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)ethyl]-N-methylamino]ethyl]benzenemethanol
CAS No. 108767-50-6, 90845-56-0 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Soc. Esp. Esp. Farmaco-Terap閡ticas (Originator)
合成路线:The title compound has been synthesized by alkylation of ephedrine (II) with the chloroethylidene derivative (I).
📌 参考资料/链接：
参考文献标题:New cpds.derived from diphenyl-methylene-ethylamine
文献作者:Cirera,X.D.; Bruseghini,L.; Andreoli,R.R.; Irrure,J.P.; Lloveras,P.P.(Sociedad Espa駉la de Especialidades Farmaco-Terap閡ticas SA)
参考来源:EP 0132764; US 5112826
📄 详细内容
合成路线:In a related procedure,aldehyde (III) was condensed with ephedrine (II) under azeotropic removal of water,affording oxazolidine (IV).Subsequent reduction of (IV) using NaBH4 furnished the title compound.
参考文献标题:Preparation of a deriv.of 2-amino-1-phenylpropan-1-ol
文献作者:Andreoli,R.; Forn? E.; Cepero,R.(Sociedad Espa駉la de Especialidades Farmaco-Terap閡ticas SA)
参考来源:ES 2017278
产品链接: CAS No.90845-56-0››