合成路线:It can be prepared in four different ways:1) By a Friedel-Crafts reaction of 1,2,4-triethoxybenzene (I) with succinic anhydride (II) by means of AlCl3 in tetrachloroethane (1).2) The Friedel-Crafts reaction of (I) with maleic anhydride (III) by means of AlCl3 gives trans-3-(2,4,5-triethoxybenzoyl)acrylic acid (IV),which is then hydrogenated with H2 over Pd/C (2).3) The condensation of (I) with succinic acid half ethyl ester (V) by means of polyphosphoric acid gives ethyl 3-(2,4,5-triethoxybenzoyl)propionate (VI),which is then hydrolyzed with NaOH (3).
参考文献标题:
文献作者:
参考来源:AU 319215
合成路线:It can be prepared in four different ways:1) By a Friedel-Crafts reaction of 1,2,4-triethoxybenzene (I) with succinic anhydride (II) by means of AlCl3 in tetrachloroethane (1).2) The Friedel-Crafts reaction of (I) with maleic anhydride (III) by means of AlCl3 gives trans-3-(2,4,5-triethoxybenzoyl)acrylic acid (IV),which is then hydrogenated with H2 over Pd/C (2).3) The condensation of (I) with succinic acid half ethyl ester (V) by means of polyphosphoric acid gives ethyl 3-(2,4,5-triethoxybenzoyl)propionate (VI),which is then hydrolyzed with NaOH (3).
参考文献标题:
文献作者:Murata,T.
参考来源:JP 7372151
合成路线:4) The condensation of 2,4,5-triethoxyphenacyl chloride (VII) with ethyl malonate (VIII) by means of NaOH gives diethyl 2,4,5-triethoxyphenacylmalonate (IX),which is finally hydrolyzed and decarboxylated in hot 30% H2SO4.
参考文献标题:
文献作者:
参考来源:AU 321285
合成路线:It can be prepared in four different ways:1) By a Friedel-Crafts reaction of 1,2,4-triethoxybenzene (I) with succinic anhydride (II) by means of AlCl3 in tetrachloroethane (1).2) The Friedel-Crafts reaction of (I) with maleic anhydride (III) by means of AlCl3 gives trans-3-(2,4,5-triethoxybenzoyl)acrylic acid (IV),which is then hydrogenated with H2 over Pd/C (2).3) The condensation of (I) with succinic acid half ethyl ester (V) by means of polyphosphoric acid gives ethyl 3-(2,4,5-triethoxybenzoyl)propionate (VI),which is then hydrolyzed with NaOH (3).
合成路线:4) The condensation of 2,4,5-triethoxyphenacyl chloride (VII) with ethyl malonate (VIII) by means of NaOH gives diethyl 2,4,5-triethoxyphenacylmalonate (IX),which is finally hydrolyzed and decarboxylated in hot 30% H2SO4.
参考文献标题:Trepibutone
文献作者:Sungurbey,K.
参考来源:Drugs Fut 1978,3(11),846
产品链接: CAS No. 41826-92-0››