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项目整合精选>>>Azolastone, Mitozolomide, CCRG-81080, NSC-353451, M&B-39565, 46241-RP
Azolastone, Mitozolomide, CCRG-81080, NSC-353451, M&B-39565, 46241-RP
米托唑胺Chemical Name: 3-(2-Chloroethyl)-3,4-dihydro-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide; 8-Carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one
CAS No. 85622-95-3
项目整合开发状态: Phase II
项目研究机构: May & Baker (Originator)
合成路线:By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.
合成路线:By reaction of 5-diazoimidazole-4-carboxamide (II),prepared by diazotization of 5-aminoimidazole-4-carboxamide (I) with nitrous acid,with methylisocyanate (III) either alone or in dichloromethane.
📌 参考资料/链接：
参考文献标题:Tetrazine derivs.,process for their preparation and pharmaceutical compsns.containing them
文献作者:Lunt,E.; Stevens,M.F.G.; Stone,R.; Woolbridge,K.R.H.(Cancer Research Campaign Technology Ltd.)
参考来源:BE 894175; DE 3231255; FR 2511679; GB 2104522; JP 1983043975; US 5260291
📄 详细内容
合成路线:By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.
参考文献标题:Mitozolomide
文献作者:Hopkins,S.J.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(11),827
合成路线:By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.
合成路线:By reaction of 5-diazoimidazole-4-carboxamide (II),prepared by diazotization of 5-aminoimidazole-4-carboxamide (I) with nitrous acid,with methylisocyanate (III) either alone or in dichloromethane.
参考文献标题:Antitumor imidazotetrazinones.1.Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one,a novel broad-spectrum antitumor agent
文献作者:Stone,R.; Newton,C.G.; Gibson,N.W.; Baig,G.U.; Lunt,E.; Stevens,M.F.G.; Hickman,J.A.
参考来源:J Med Chem 1984,27(196-201),196
合成路线:By cyclization of 5-diazoimidazole-4-carboxamide (I) with 2-chloroethyl isocyanate (II) in dichloromethane.
参考文献标题:The role of isocyanates in the toxicity of antitumor haloalkylnitrosoureas
文献作者:Gibson,N.W.; Hickman,J.A.
参考来源:Biochem Pharmacol 1982,31(17),2795-2800
产品链接: CAS No. 85622-95-3››