Midostaurin, PKC-412, CGP-41251
米哚妥林Chemical Name: N-[(9S,10R,11R,13R)-10-Methoxy-9-methyl-1-oxo-9,13-epoxy-2,3,10,11,12,13-hexahydro-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide; N-Benzoylstaurosporine
CAS No. 120685-11-2
项目整合开发状态: Phase II
项目研究机构: Novartis (Originator), Johns Hopkins University (Codevelopment)
合成路线:The title benzamide was prepared by acylation of the alkaloid staurosporine (I) with benzoyl chloride (II) in the presence of diisopropylethylamine in chloroform.
📌 参考资料/链接：
参考文献标题:Staurosporine derivs.substd.for the nitrogen atom of the methylamino group
文献作者:Caravatti,G.; Fredenhagen,A.(Novartis AG)
参考来源:EP 0296110; JP 1989034989; US 5093330
📄 详细内容
合成路线:The title benzamide was prepared by acylation of the alkaloid staurosporine (I) with benzoyl chloride (II) in the presence of diisopropylethylamine in chloroform.
参考文献标题:Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C
文献作者:Caravatti,G.; et al.
参考来源:Bioorg Med Chem Lett 1994,4(3),399
产品链接: CAS No. 120685-11-2››