Milrinone lactate, YM-018, Win-47203, Corotrope, Primacor
米力农Chemical Name: 2-Methyl-6-oxo-1,6-dihydro-[(3,4'-bipyridine)-5-carbonitrile lactate
CAS No. 78415-72-2 (free base)
项目整合开发状态: Launched-1988
项目研究机构: Sanofi-Aventis (Originator)
合成路线:The condensation of ethyl acetate (I) with 4-picoline (II) by means of n-butyllithium in THF gives 1-(4-pyridyl)propanone (III),which by reaction with the dimethylacetal of dimethylformamide (IV) in refluxing HMPT is converted into 4-dimethylamino-3-(4-pyridyl)-3-buten-2-one (V).Finally,this compound is cyclized with cyanacetamide (VI) by means of sodium methoxide in refluxing DMF.
📌 参考资料/链接：
参考文献标题:5-(pyridinyl)-2(1H)-pyridinones,useful as cardiotonic agents and their preparation
文献作者:Lehser,G.Y.; Philion,R.E.; Page,D.F.; Opalka,C.J.(Sterling Winthrop Inc.)
参考来源:DE 3044568; FR 2470124; GB 2065642; NL 8006399
📄 详细内容
合成路线:The condensation of ethyl acetate (I) with 4-picoline (II) by means of n-butyllithium in THF gives 1-(4-pyridyl)propanone (III),which by reaction with the dimethylacetal of dimethylformamide (IV) in refluxing HMPT is converted into 4-dimethylamino-3-(4-pyridyl)-3-buten-2-one (V).Finally,this compound is cyclized with cyanacetamide (VI) by means of sodium methoxide in refluxing DMF.
参考文献标题:WIN-47,203
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(10),757
产品链接: CAS No. 78415-72-2››