Fotemustine, S-10036, Servier-10036, Muphoran
福莫司汀Chemical Name: (?-[1-[3-(2-Chloroethyl)-3-nitrosoureido]ethyl]phosphonic acid diethyl ester
CAS No. 92118-27-9
项目整合开发状态: Launched-1990
项目研究机构: ADIR (Originator), Servier (Originator), Italfarmaco (Licensee)
合成路线:The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III),which is then treated with sodium nitrite and formic acid.
📌 参考资料/链接：
参考文献标题:New nitrosourea derivs.,process for preparing them and pharmaceutical compsns.containing them
文献作者:Lavielle,G.; Cudennec,C.(ADIR et Cie.)
参考来源:FR 2536075
📄 详细内容
合成路线:The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III),which is then treated with sodium nitrite and formic acid.
参考文献标题:FOTEMUSTINE < Rec INN >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(11),1042
产品链接: CAS No. 92118-27-9››