Iobitridol, Xenetix
碘比醇Chemical Name: N,N'-Bis(2,3-dihydroxypropyl)-5-[3-hydroxy-2-(hydroxymethyl)propionamido]-2,4,6-triiodo-N,N'-dimethylisophthalamide
CAS No. 136949-58-1
项目整合开发状态: Launched-1995
项目研究机构: Guerbet (Originator), Mitsubishi Chemical (Licensee), Mitsubishi Pharma (Licensee)
合成路线:Acylation of 5-amino-2,4,6-triiodoisophthaloyl chloride (I) with 2-isopropyl-1,3-dioxane-5-carbonyl chloride (II) provided the amido isophthaloyl chloride (III).Acid chloride (III) was then condensed with 3-(methylamino)-1,2-propanediol (IV) to furnish the triamide compound (V).The acetal protecting group was finally removed under acidic conditions.
📌 参考资料/链接：
参考文献标题:Non-ionic iodinated cpds.,procedure for their preparation and contrast agents containing them
文献作者:Schaefer,M.; Dugast-Zrihen,M.; Guillemot,M.; Doucet,D.; Meyer,D.(Guerbet SA)
参考来源:EP 0437144; WO 9109836
📄 详细内容
合成路线:Acylation of 5-amino-2,4,6-triiodoisophthaloyl chloride (I) with 2-isopropyl-1,3-dioxane-5-carbonyl chloride (II) provided the amido isophthaloyl chloride (III).Acid chloride (III) was then condensed with 3-(methylamino)-1,2-propanediol (IV) to furnish the triamide compound (V).The acetal protecting group was finally removed under acidic conditions.
参考文献标题:Iodinated non-ionic triiodobenzene cpds.and contrast media containing them
文献作者:Meyer,D.; Doucet,D.; Guillemot,M.; Dugast-Zrihen,M.; Schaefer,M.(Guerbet SA)
参考来源:US 5043152
产品链接: CAS No. 136949-58-1››