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项目整合精选>>>Butoconazole nitrate, RS-35887-00-10-3, RS-35887, Gynomyk, Gynazole-1, Femstat
Butoconazole nitrate, RS-35887-00-10-3, RS-35887, Gynomyk, Gynazole-1, Femstat
硝酸布康唑 布康唑 Chemical Name: (?-1-[4-(p-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]imidazole mononitrate
CAS No. 64872-77-1, 64872-76-0 (free base)
项目整合开发状态: Launched-1986
项目研究机构: Roche Bioscience (Originator), Bayer (Not Determined), Cassenne (Not Determined), KV Pharmaceutical (Not Determined), Arrow Pharmaceuticals (Marketer), Ferring (Licensee)
合成路线:The chlorohydrin (II) is obtained by the reaction of p-chlorobenzylmagnesium chloride (I) with epichlorohydrin (A) in ether.This is then converted to the crystalline alcohol (III) by reaction with sodium imidazole (B) in DMF.On treatment with thionyl chloride is converted to the corresponding chloro compound (IV).When (IV) is reacted with 2,6-dichloro thiophenol (C) in the presence of anhydrous potassium carbonate in acetone,the free base of butoconazole is formed.Neutralization of the free base (V) with nitric acid gives butoconazole.
📌 参考资料/链接：
参考文献标题:Butoconazole nitrate
文献作者:Arya,V.P.
参考来源:Drugs Fut 1979,4(2),89
📄 详细内容
合成路线:The chlorohydrin (II) is obtained by the reaction of p-chlorobenzylmagnesium chloride (I) with epichlorohydrin (A) in ether.This is then converted to the crystalline alcohol (III) by reaction with sodium imidazole (B) in DMF.On treatment with thionyl chloride is converted to the corresponding chloro compound (IV).When (IV) is reacted with 2,6-dichloro thiophenol (C) in the presence of anhydrous potassium carbonate in acetone,the free base of butoconazole is formed.Neutralization of the free base (V) with nitric acid gives butoconazole.
参考文献标题:1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenylthio)n-butil]-1H-imidazole nitrate,a new patent antifungal agent
文献作者:Walker,K.A.M.; Braemer,A.C.; Hitt,S.; Jones,R.E.; Matthews,T.R.
参考来源:J Med Chem 1978,21(8),840
产品链接: CAS No. 64872-77-1›› 产品链接: CAS No.64872-76-0››