合成路线:The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III),which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1).Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).
参考文献标题:
文献作者:Lappas,L.C.; Hirsch,C.A.
参考来源:DE 2407289; FR 2218096; JP 74110674; NL 7402164; ZA 7400493
合成路线:The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III),which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1).Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).
参考文献标题:Substituted 5-nitro-1,3-dioxanes: correlation of chemical structure and antimicrobial activity
文献作者:Lappas,L.C.; et al.
参考来源:J Pharm Sci 1979,65(9),1301-1305
合成路线:The condensation of nitromethane (I) with formaldehyde (II) by means of NaOH in water gives 2-nitropropane-1,3-diol (III),which is brominated with Br2 in ethyl acetate yielding 2-bromo-2-nitropropane-1,3-diol (IV) (1).Finally this compound is condensed with acetaldehyde (V) by means of p-toluenesulfonic acid in refluxing benzene (1-3).
参考文献标题:Nibroxane
文献作者:Hillier,K.
参考来源:Drugs Fut 1979,4(5),348
产品链接: CAS No. 53983-00-9››