合成路线:Nevadensin can be synthesized starting from methyl 2,6-dimethoxyphenyl acetate (I).This compound is nitrated and then hydrogenated,giving methyl 3,5-diamino-2,6-dimethoxyphenyl acetate (III).Treatment of the latter compound with stannous chloride-hydrochloric acid gives dimethoxyphloroglucinol (IV).Introduction of an acetyl group followed by interaction with p-methoxybenzoyl chloride (A) gives 4-acetyl-2,6-dimethoxyphloroglucinyl tri(p-methoxy) benzoate (VI).The latter compound,after being rearranged,is cyclized into 5,7-di(p-methoxy)benzoylnevadensin (VIII).Nevadensin can readily be obtained by the hydrolysis of the compound (VIII).
参考文献标题:Studies on the antituberculosis principles from Lysionotus pauciflora Maxim.I.Isolation and identification of nevadensin
文献作者:Feng,S.; Xu,Y.; Fan,G.
参考来源:Acta Pharm Sin 1979,14(7),447-448
合成路线:Nevadensin can be synthesized starting from methyl 2,6-dimethoxyphenyl acetate (I).This compound is nitrated and then hydrogenated,giving methyl 3,5-diamino-2,6-dimethoxyphenyl acetate (III).Treatment of the latter compound with stannous chloride-hydrochloric acid gives dimethoxyphloroglucinol (IV).Introduction of an acetyl group followed by interaction with p-methoxybenzoyl chloride (A) gives 4-acetyl-2,6-dimethoxyphloroglucinyl tri(p-methoxy) benzoate (VI).The latter compound,after being rearranged,is cyclized into 5,7-di(p-methoxy)benzoylnevadensin (VIII).Nevadensin can readily be obtained by the hydrolysis of the compound (VIII).
参考文献标题:Determination of nevadensin in biological specimens and its pharmacokinetic study
文献作者:Su,C.; Han,G.; Zhang,Y.
参考来源:Chin Pharm Bull 1981,2(3),182-185
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