合成路线:The condensation of 3-methylphenol (I) and epichlorohydrin (II) by means of NaOH gives 1,2-epoxy-3-(3-methylphenoxy)propane (III),which is then condensed with 3,4-dimethoxyphenylethylamine (V) by heating their mixture at 95-100 C.
合成路线:The condensation of 3-methylphenol (I) with epichlorohydrin (II) by means of a catalytic amount of piperidine gives 1-(3-methylphenoxy)-3-chloro-2-propanol (IV),which is then condensed with 3,4-dimethoxyphenylethylamine (V) by heating their mixture at 95-100 C.
参考文献标题:Cardioselective beta-adrenergic blocking agents.1.1-[3,4-(dimethoxyphenethyl)amino]-3-aryloxy-2-propanols
文献作者:Hoefle,M.L.; Hastings,S.G.; Meyer,R.F.; Corey,R.M.; Holmes,A.; Stratton,C.D.
参考来源:J Med Chem 1975,18(2),148-152
合成路线:The condensation of 3-methylphenol (I) and epichlorohydrin (II) by means of NaOH gives 1,2-epoxy-3-(3-methylphenoxy)propane (III),which is then condensed with 3,4-dimethoxyphenylethylamine (V) by heating their mixture at 95-100 C.
合成路线:The condensation of 3-methylphenol (I) with epichlorohydrin (II) by means of a catalytic amount of piperidine gives 1-(3-methylphenoxy)-3-chloro-2-propanol (IV),which is then condensed with 3,4-dimethoxyphenylethylamine (V) by heating their mixture at 95-100 C.
参考文献标题:New aminoalkanol compounds and methods for their production
文献作者:Holmes,A.; Meyer,R.F.
参考来源:FR 2163486; GB 1344976; JP 48067232
产品链接: CAS No. 42864-78-8›› 产品链接: CAS No.59170-23-9››