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项目整合精选>>>Cinacalcet hydrochloride, AMG-073, KRN-1493, AMG-073.HCl, Parareg, Mimpara, Sensipar
Cinacalcet hydrochloride, AMG-073, KRN-1493, AMG-073.HCl, Parareg, Mimpara, Sensipar
盐酸西那卡塞 西那卡塞 Chemical Name: N-[1(R)-(1-Naphthyl)ethyl]-N-[3-[3-(trifluoromethyl)phenyl]propyl]amine hydrochloride
CAS No. 364782-34-3, 226256-56-0 (free base)
项目整合开发状态: Launched-2004
项目研究机构: Amgen (Orphan Drug), NPS Allelix (Originator), Amgen (Licensee), Kirin Brewery (Licensee)
合成路线:Reaction of 1(R)-(1-naphthyl)ethylamine (I) with 3-[3-(trifluoromethyl)phenyl]propionaldehyde (II) by means of titanium tetraisopropoxide gives the corresponding imine (III),which is finally reduced with NaBH3CN in ethanol.
📌 参考资料/链接：
参考文献标题:Calcium receptor-active cpds.
文献作者:Moe,S.T.; Balandrin,M.F.; Van Wagenen,B.C.; Nemeth,E.F.; DelMar,E.G.(NPS Pharmaceuticals,Inc.)
参考来源:US 6211244
📄 详细内容
合成路线:Reaction of 1(R)-(1-naphthyl)ethylamine (I) with 3-[3-(trifluoromethyl)phenyl]propionaldehyde (II) by means of titanium tetraisopropoxide gives the corresponding imine (III),which is finally reduced with NaBH3CN in ethanol.
参考文献标题:Cinacalcet Hydrochloride
文献作者:Bay閟,M.; Castar,R.M.; Sorbera,L.A.
参考来源:Drugs Fut 2002,27(9),831
产品链接: CAS No. 364782-34-3›› 产品链接: CAS No.226256-56-0››