Memantine hydrochloride, SUN-Y7017, NMI-131, D-145, Namenda, Axura, Ebixa, Akatinol

盐酸美金刚 3,5-二甲基金刚胺 Chemical Name: 3,5-Dimethyl-1-adamantanamine hydrochloride; 3,5-Dimethyltricyclo[3,3,1,1(3,7)]decan-1-amine hydrochloride
CAS No. 41100-52-1, 19982-08-2 (free base)
项目整合开发状态: Launched-1982
项目研究机构: Merz (Originator), Allergan (Not Determined), Daiichi Suntory Pharma (Licensee), Forest (Licensee), Lundbeck (Licensee), Neurobiological Technologies (Licensee), National Institutes of Health (Codevelopment)
合成路线:The reaction of 1-bromo-3,5-dimethyladamantane (I) with Li in ethyl ether gives the corresponding lithium derivative,which is treated with NH2-Cl (II) to afford the target 1-aminoadamantane.