Amiprilose, SM-1213, Therafectin
盐酸氨普立糖 盐酸氨普立糖 Chemical Name: 3-O-[3-(Dimethylamino)propyl]-1,2-O-(1-methylethylidene)-alpha-D-glucofuranose; 1,2-O-Isopropylidene-3-O-[3'-(N,N-dimethylamino)propyl]-D-glucofuranose
CAS No. 56824-20-5, 60414-06-4 (HCl)
项目整合开发状态: Phase III
项目研究机构: Boston Life Sciences (Originator), Kissei (Licensee)
合成路线:The reaction of 1,2:5.6-di-O-isopropyliden-D-glucofuranose (I) with 3-chloro-N,N-dimethylaminopropane (II) by means of NaOH in refluxing dioxane gives 1,2:5,6-di-O-isopropylidene-3-O-[3'-(N,N-dimethylamino)propyl]-D-gluco-furanose (III),which is partially hydrolyzed with HCl in water.
📌 参考资料/链接：
参考文献标题:Method of enhancing learning and/or memory in warm blooded animals
文献作者:Gordon,P.(Boston Life Sciences,Inc.)
参考来源:US 3965262
📄 详细内容
合成路线:The reaction of 1,2:5.6-di-O-isopropyliden-D-glucofuranose (I) with 3-chloro-N,N-dimethylaminopropane (II) by means of NaOH in refluxing dioxane gives 1,2:5,6-di-O-isopropylidene-3-O-[3'-(N,N-dimethylamino)propyl]-D-gluco-furanose (III),which is partially hydrolyzed with HCl in water.
参考文献标题:Therafectin
文献作者:Hopkins,S.J.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1985,10(4),301
产品链接: CAS No. 56824-20-5›› 产品链接: CAS No.60414-06-4››