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项目整合精选>>>Butenafine hydrochloride, 501 cream(combination with betamethasone dipropionate), KP-363, Volley, Mentax
Butenafine hydrochloride, 501 cream(combination with betamethasone dipropionate), KP-363, Volley, Mentax
盐酸布替萘芬 布替萘芬 Chemical Name: N-Methyl-N-(4-tert-butylbenzyl)-1-naphthylmethylamine hydrochloride; 4-tert-Butyl-N-methyl-N-(1-napthylmethyl)benzylamine hydrochloride
CAS No. 101827-46-7, 101828-21-1 (free base)
项目整合开发状态: Launched-1992
项目研究机构: Kaken (Originator), Bertek (Licensee), Schering-Plough (Licensee), UCB (Licensee), Hisamitsu (Formulation)
合成路线:By condensation of N-methyl-1-naphthylmethylamine (I) with 4-(tert-butyl)benzyl bromide (II) by means of Na2CO3 in DMF,followed by acidification with HCl in ethanol.
📌 参考资料/链接：
参考文献标题:Benzylamine derivatives,process for production thereof,and use thereof
文献作者:Arai,K.; Arita,M.; Sedino,T.; Komoto,N.; Hirose,S.(Mitsui Toatsu Chem.; Inc.)
参考来源:EP 0221781
📄 详细内容
合成路线:By condensation of 1-(chloromethyl)naphthalene (I) with N-(4-tert-butylbenzyl)-N-methylamine (II) by means of sodium carbonate in hot DMF.
参考文献标题:Amine derivs.and fungicides containing the same
文献作者:Maeda,T.; Koshikawa,S.; Yamamoto,T.; Sasaki,K.; Yokoo,M.; Amemiya,K.; Hashimoto,R.; Arika,T.; Takase,M.(Kaken Pharmaceutical Co.,Ltd.)
参考来源:US 5021458
合成路线:By condensation of N-methyl-1-naphthylmethylamine (I) with 4-(tert-butyl)benzyl bromide (II) by means of Na2CO3 in DMF,followed by acidification with HCl in ethanol.
参考文献标题:KP-363
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(4),315
产品链接: CAS No. 101827-46-7›› 产品链接: CAS No.101828-21-1››