合成路线:The reaction of 5-hydroxy-7-tetralone (I) with epichlorohydrin (I) at reflux temperature gives 5-(3-chloro-2-hydroxypropoxy)-7-tetralone (III),which is then condensed with butylamine (IV) in refluxlng alcohol.
参考文献标题:Levobunolol Hydrochloride
文献作者:Castar,J.; Serradell,M.N.; Weetman,D.F.; Blancafort,P.
参考来源:Drugs Fut 1983,8(9),788
合成路线:It can be obtained in two different ways both starting from the sodium salt of 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone (I):1) Its condensation with epichlorhydrine (A) in ethanol gives 5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone (II),which is then condensed with tert-butylamine (B) in refluxing ethanol.2) Its condensation with 3-chloro-1,2-propanediol (C) gives 5-(2,3-dihydroxy-propoxy)-3,4-dihydro-1(2H)-naphthalenone (III),which is esterified with tosyl chloride to the sulfonic ester (IV),and finally condensed with tert-butylamine.
参考文献标题:Bunolol
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(9),403
合成路线:It can be obtained in two different ways both starting from the sodium salt of 5-hydroxy-3,4-dihydro-1(2H)-naphthalenone (I):1) Its condensation with epichlorhydrine (A) in ethanol gives 5-(2,3-epoxypropoxy)-3,4-dihydro-1(2H)-naphthalenone (II),which is then condensed with tert-butylamine (B) in refluxing ethanol.2) Its condensation with 3-chloro-1,2-propanediol (C) gives 5-(2,3-dihydroxy-propoxy)-3,4-dihydro-1(2H)-naphthalenone (III),which is esterified with tosyl chloride to the sulfonic ester (IV),and finally condensed with tert-butylamine.
参考文献标题:Synthesis of 14C-labeled Bunolol
文献作者:Merrill,E.J.
参考来源:J Pharm Sci 1971,60(10),1589-91
产品链接: CAS No. 27912-14-7›› 产品链接: CAS No.47141-42-4››