合成路线:The cyclization of 2-amino-4'-bromobenzophenone (I) with ethyl 2-(methylthio)acetate (II) by means of tert-butyl hypochlorite in dichloromethane at 70 C gives 7-(4-bromobenzoyl)-3-(methylthio)-2,3-dihydro-1H-indol-2-one (III),which is desulfurized by a treatment with Raney Nickel in THF yielding 7-(4-bromobenzoyl)-2,3-dihydro-1H-indol-2-one (IV).Finally,this compound is hydrolyzed with refluxing 3N NaOH and acidified with concentrated HCl.
参考文献标题:Method of lowering intraocular pressure using phenylimino-imidazoles
文献作者:Cavero,I.; Langer,S.Z.; York,B.M.Jr.
参考来源:US 4515800
合成路线:The cyclization of 2-amino-4'-bromobenzophenone (I) with ethyl 2-(methylthio)acetate (II) by means of tert-butyl hypochlorite in dichloromethane at 70 C gives 7-(4-bromobenzoyl)-3-(methylthio)-2,3-dihydro-1H-indol-2-one (III),which is desulfurized by a treatment with Raney Nickel in THF yielding 7-(4-bromobenzoyl)-2,3-dihydro-1H-indol-2-one (IV).Finally,this compound is hydrolyzed with refluxing 3N NaOH and acidified with concentrated HCl.
参考文献标题:Aplonidine hydrochloride
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(6),507
产品链接: CAS No. 73218-79-8››