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Ozagrel hydrochloride, OKY-046, Vega, Domenan

盐酸奥扎格雷 奥扎格雷 Chemical Name: (E)-4-(Imidazol-1-ylmethyl)cinnamic acid monohydrochloride monohydrate; (E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid monohydrochloride monohydrate
CAS No. 78712-43-3 (anhydrous), 82571-53-7 (anhydrous free base)
项目整合开发状态: Launched-1992
项目研究机构: Kissei (Originator), Ono (Originator)
合成路线:The condensation of ethyl 4-(bromomethyl)cinnamate (I) with imidazole (II) by means of NaH in DMF give ethyl 4-(1-imidazolylmethyl)cinnamate (III),wich is hydrolyzed with NaOH in methanol - water,and acidified with HCl.

合成路线:The condensation of ethyl 4-(bromomethyl) cinnamate (I) with imidazole (II) by means of NaH in DMF gives ethyl 4-(1-imidazolylmethyl) cinnamate (III),which is hydrolyzed with NaOH in methanol / water,and acidified with HCl.
📌 参考资料/链接:
参考文献标题:Imidazole derivative
文献作者:Iizuka,K.; Akahane,K.; Kamijo,Y.; Momose,D.; Matsumoto,A.; Yukiyoshi,O.(Kissei Pharmaceutical Co.,Ltd.; Ono Pharmaceutical Co.,Ltd.)
参考来源:DE 2923815; GB 2025946; US 4226878

📄 详细内容


合成路线:The condensation of ethyl 4-(bromomethyl)cinnamate (I) with imidazole (II) by means of NaH in DMF give ethyl 4-(1-imidazolylmethyl)cinnamate (III),wich is hydrolyzed with NaOH in methanol - water,and acidified with HCl.

合成路线:The condensation of ethyl 4-(bromomethyl) cinnamate (I) with imidazole (II) by means of NaH in DMF gives ethyl 4-(1-imidazolylmethyl) cinnamate (III),which is hydrolyzed with NaOH in methanol / water,and acidified with HCl.

参考文献标题:OKY-046
文献作者:Blancafort,P.; Serradell,M.N.; Pento,J.T.; Castar,J.
参考来源:Drugs Fut 1983,8(4),328


合成路线:The condensation of ethyl 4-(bromomethyl)cinnamate (I) with imidazole (II) by means of NaH in DMF give ethyl 4-(1-imidazolylmethyl)cinnamate (III),wich is hydrolyzed with NaOH in methanol - water,and acidified with HCl.

合成路线:The condensation of ethyl 4-(bromomethyl) cinnamate (I) with imidazole (II) by means of NaH in DMF gives ethyl 4-(1-imidazolylmethyl) cinnamate (III),which is hydrolyzed with NaOH in methanol / water,and acidified with HCl.
参考文献标题:The protaglandins: A family of biologically active lipids
文献作者:Bergstrom,S.; Carlson,L.A.; Weeks,J.R.
参考来源:J Med Chem 1981,24(10),409-412


产品链接: CAS No. 78712-43-3››

产品链接: CAS No.82571-53-7››