Detomidine hydrochloride, Domosedan
盐酸地托咪定 地托咪定 Chemical Name: 4-(2,3-Dimethylbenzyl)imidazole hydrochloride
CAS No. 90038-01-0, 76631-46-4 (free base)
项目整合开发状态: Launched-1984
项目研究机构: Orion Pharma (Originator)
合成路线:The Grignard condensation of imidazole-4-carboxaldehyde (I) with 2,3-dimethylphenylmagnesium bromide (II) in THF gives 4-(alpha-hydroxy-2,3-dimethylbenzyl)imidazole (III),which is then hydrogenated with H2 over Pd/C in aqueous 4N HCl.
📌 参考资料/链接：
参考文献标题:4-Benzyl- and 4-benzoyl-substituted imidazole derivatives and use as medicaments
文献作者:Karjalainen,A.J.; Kurkela,K.O.A.(Orion Corporation)
参考来源:DD 152548; EP 0024829; JP 56032463; US 4443466
📄 详细内容
合成路线:The Grignard condensation of imidazole-4-carboxaldehyde (I) with 2,3-dimethylphenylmagnesium bromide (II) in THF gives 4-(alpha-hydroxy-2,3-dimethylbenzyl)imidazole (III),which is then hydrogenated with H2 over Pd/C in aqueous 4N HCl.
参考文献标题:Detomidine Hydrochloride
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1985,10(1),17
产品链接: CAS No. 90038-01-0›› 产品链接: CAS No.76631-46-4››