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项目整合精选>>>Ticlopidine hydrochloride, 4-C-32, 53-32C, Panaldine, Tiklyd, Tiklid, Ipaton, Ticlodone, Ticlodix, Ticlid
Ticlopidine hydrochloride, 4-C-32, 53-32C, Panaldine, Tiklyd, Tiklid, Ipaton, Ticlodone, Ticlodix, Ticlid
盐酸噻氯匹定 噻氯匹啶 Chemical Name: 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride
CAS No. 53885-35-1, 55142-85-3 (free base)
项目整合开发状态: Launched-1978
项目研究机构: Roche Bioscience (Originator), Sanofi-Aventis (Originator), Daiichi Pharmaceutical (Not Determined), Egis (Not Determined), Almirall Prodesfarma (Licensee)
合成路线:By condensation of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (I) and 2-chlorobenzyl chloride (II) with K2CO3 in refluxing ethanol or by reaction of thieno[3,2-c]pyridine (III) with 2-chlorobenzyl chloride (II) in refluxing acetonitrile to give the thienopyridinium salt (IV),which is then reduced with NaBH4 in ethanol-water.
📌 参考资料/链接：
参考文献标题:Ticlopidine
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(4),190
📄 详细内容
合成路线:By condensation of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine (I) and 2-chlorobenzyl chloride (II) with K2CO3 in refluxing ethanol or by reaction of thieno[3,2-c]pyridine (III) with 2-chlorobenzyl chloride (II) in refluxing acetonitrile to give the thienopyridinium salt (IV),which is then reduced with NaBH4 in ethanol-water.
参考文献标题:Synth鑣e d thi閚opyridines et de furopyridines d'int閞阾 th閞apeutique
文献作者:Eloy,F.; Maffrand,J.P.
参考来源:Eur J Med Chem 1974,9483
产品链接: CAS No. 53885-35-1›› 产品链接: CAS No.55142-85-3››