合成路线:The cyclization of catechol (I) with 2-chloroacrylonitrile (II) by means of K2CO3 in acetone gives 2-cyanobenzo-1,4-dioxane (III),which is hydrolyzed with ethanol and HCl to the corresponding iminoether (IV) Finally,this compound is cyclized with ethylenediamine (V) in cool ethanol.
参考文献标题:Idazoxan hydrochloride
文献作者:Hillier,K.
参考来源:Drugs Fut 1983,8(9),778
合成路线:The cyclization of catechol (I) with 2-chloroacrylonitrile (II) by means of K2CO3 in acetone gives 2-cyanobenzo-1,4-dioxane (III),which is hydrolyzed with ethanol and HCl to the corresponding iminoether (IV) Finally,this compound is cyclized with ethylenediamine (V) in cool ethanol.
参考文献标题:2-[2-(1,4-Benzodioxanyl)]-2-imidazoline hydrochloride
文献作者:Myers,P.L.; Chapleo,C.B.
参考来源:Tetrahedron Lett 1981,22(48),4839-42
产品链接: CAS No. 79944-56-2›› 产品链接: CAS No.79944-58-4››