Lidamidine hydrochloride, WHR-1142A, Lidaral
盐酸利达咪定 利达脒 Chemical Name: 1-(2,6-Dimethylphenyl)-3-methylamidino urea hydrochloride
CAS No. 65009-35-0, 66871-56-5 (free base)
项目整合开发状态: Launched-1984
项目研究机构: Aventis Pharma (Originator), Yamanouchi (Originator), Valeant (Licensee)
合成路线:The reaction of 2,6-dimethylaniline (I) with phosgene (II) in refluxing benzene gives 2,6-dimethylphenyl isocyanate (III),which is then condensed with methylguanidine carbonate (A) by means of K2CO3 in THF and treated with HCl to obtain the corresponding hydrochloride.
📌 参考资料/链接：
参考文献标题:Lidamidine hydrochloride
文献作者:Roberts,P.J.; Castar,J.
参考来源:Drugs Fut 1979,4(3),206
📄 详细内容
合成路线:The reaction of 2,6-dimethylaniline (I) with phosgene (II) in refluxing benzene gives 2,6-dimethylphenyl isocyanate (III),which is then condensed with methylguanidine carbonate (A) by means of K2CO3 in THF and treated with HCl to obtain the corresponding hydrochloride.
参考文献标题:Nouvelles amidinour閑s,leur pr閜aration et leur emploi
文献作者:
参考来源:BE 0844832
产品链接: CAS No. 65009-35-0›› 产品链接: CAS No.66871-56-5››