合成路线:By bromination of 4-amino-3,5-dichloroacetophenone (I) with Br2 in CHCl3 to give 4-amino-3,5-dichloro-alpha-bromoacetophenone (II),m.p.140-5 C,which is condensed with tert-butylamine (III) in CHCl3 to 4-amino-3,5-dichloro-alpha-tertbutylaminoacetophenone hydrochloride (IV),m.p.252-7 C; this product is finally reduced with NaBH4 in methanol.
参考文献标题:Synthesen von neuen Amino-Halogen-substituierten Phenyl-amino鋞hanolen
文献作者:Keck,J.; et al.
参考来源:Arzneim-Forsch Drug Res 1972,22(5),861-869
合成路线:By bromination of 4-amino-3,5-dichloroacetophenone (I) with Br2 in CHCl3 to give 4-amino-3,5-dichloro-alpha-bromoacetophenone (II),m.p.140-5 C,which is condensed with tert-butylamine (III) in CHCl3 to 4-amino-3,5-dichloro-alpha-tertbutylaminoacetophenone hydrochloride (IV),m.p.252-7 C; this product is finally reduced with NaBH4 in methanol.
参考文献标题:Neue Verbindung 1-(4-Amino-3,5-dichlorphenyl)-2-tert-butylamino-鋞hanol
文献作者:Keck,J.; et al.
参考来源:DE 1793416
产品链接: CAS No. 21898-19-1›› 产品链接: CAS No.37148-27-9››