Enciprazine, Wy-48624(diHCl), D-13112
恩西拉嗪Chemical Name: (R,S)-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-[3,4,5-trimethoxyphenoxy]propan-2-ol; (?-4-(o-Methoxyphenyl)-alpha-[(3,4,5-trimethoxyphenoxy)methyl]-1-piperazineethanol
CAS No. 68576-86-3, 68576-88-5 (diHCl)
项目整合开发状态: Phase III
项目研究机构: Asta Medica (Originator), Wyeth Pharmaceuticals (Licensee)
合成路线:By reaction of 1-(3-chloro-2-hydroxypropyl)-4-(2-methoxyphenyl)piperazine (III),obtained from 2-methoxyphenylpiperazine (I) and epichlorohydrine (II),with the sodium salt of 3,4,5-trimethoxyphenol (IV) in refluxing dioxane.
合成路线:By reaction of 3,4,5-trimethoxyphenoxyglycidylether (VI) [obtained by reaction of 3,4,5-trimethoxyphenol (V) with epichlorohydrine (II)] with 1-(2-methoxyphenyl)piperazine (I) in refluxing isopropanol.
📌 参考资料/链接：
参考文献标题:Enciprazine
文献作者:Engel,J.; Jakovlev,V.; Kleemann,A.
参考来源:Drugs Fut 1981,6(5),278
📄 详细内容
合成路线:By reaction of 1-(3-chloro-2-hydroxypropyl)-4-(2-methoxyphenyl)piperazine (III),obtained from 2-methoxyphenylpiperazine (I) and epichlorohydrine (II),with the sodium salt of 3,4,5-trimethoxyphenol (IV) in refluxing dioxane.
合成路线:By reaction of 3,4,5-trimethoxyphenoxyglycidylether (VI) [obtained by reaction of 3,4,5-trimethoxyphenol (V) with epichlorohydrine (II)] with 1-(2-methoxyphenyl)piperazine (I) in refluxing isopropanol.
参考文献标题:
文献作者:Kleemann,A.
参考来源:DE 2814168
产品链接: CAS No. 68576-86-3›› 产品链接: CAS No.68576-88-5››