Isepamicin, HAPA-B, Sch-21420, Isepalline, Isepacin
异帕米星Chemical Name: 1-N-(S-3-Amino-2-hydroxypropionyl)betamycin; 1-N-(S-3-Amino-2-hydroxypropionyl)gentamycin B; (S)-O-6-Amino-6-deoxy-alpha-D-glucopyranosyl-(1--4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1--6)-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-D-streptamine
CAS No. 58152-03-7
项目整合开发状态: Launched
项目研究机构: Essex (Originator), Schering-Plough (Originator), Asahi Kasei (Licensee)
合成路线:By alkylation of sisomicin (I) with acetaldehyde (II) and sodium cyanoborohydride in water with some sulfuric acid.
合成路线:The reaction of gentamicin B sulfate (betamicin sulfate) (I) with N-(S-3-benzyloxycarbonylamino)-2-hydroxypropionylsuccinimide (II) by means of triethylamine in water-methanol-DMF gives 1-N-(S-3-benzyloxycarbonylamino-2-hydropropionyl)betamicin (III),which is finally hydrogenated with H2 over Pd/C in methanol-water.
📌 参考资料/链接：
参考文献标题:Novel pseudotrisaccharides and methods for their production
文献作者:Daniels,P.J.L.; Testa,R.; Tattanahalli,L.; Mallams,A.K.; Wright,J.J.; Weinstein,M.J.; Wagman,G.H.(Schering Corp.)
参考来源:DE 2437160; FR 2240015; GB 1473733; US 4029882
📄 详细内容
合成路线:The reaction of gentamicin B sulfate (betamicin sulfate) (I) with N-(S-3-benzyloxycarbonylamino)-2-hydroxypropionylsuccinimide (II) by means of triethylamine in water-methanol-DMF gives 1-N-(S-3-benzyloxycarbonylamino-2-hydropropionyl)betamicin (III),which is finally hydrogenated with H2 over Pd/C in methanol-water.
参考文献标题:SCH-21420
文献作者:Serradell,M.N.; Blancafort,P.; Roberts,P.J.; Castar,J.
参考来源:Drugs Fut 1979,4(7),525
产品链接: CAS No. 58152-03-7››