Phentolamine mesilate, Z-Max, Vasofem, Vasomax, Regitin
甲磺酸酚妥拉明 酚妥拉明 Chemical Name: 3-[N-(2-Imidazolin-2-ylmethyl)-N-(4-methylphenyl)amino]phenol methanesulfonate
CAS No. 65-28-1, 50-60-2 (free base)
项目整合开发状态: Launched-1950
项目研究机构: Novartis (Originator), Zonagen (Licensee)
合成路线:The condensation of N-(3-hydroxyphenyl)-N-(4-methylphenyl)amine (I) with 2-(chloromethyl)-4,5-dihydro-1H-imidazole (II) by heating at 150-60 C without solvent or in o-dichlorobenzene gives phentolamine as hydrochloride salt (III),which is treated with ammonia to obtain the free base,and finally salified with methanesulfonic acid in ethanol.
📌 参考资料/链接：
参考文献标题:2-(N,N-Diphenyl-aminomethyl)imidazoles
文献作者:Miescher,K.; Marxer,A.; Urech,E.(Novartis Corp.)
参考来源:US 2503059
📄 详细内容
合成路线:The condensation of N-(3-hydroxyphenyl)-N-(4-methylphenyl)amine (I) with 2-(chloromethyl)-4,5-dihydro-1H-imidazole (II) by heating at 150-60 C without solvent or in o-dichlorobenzene gives phentolamine as hydrochloride salt (III),which is treated with ammonia to obtain the free base,and finally salified with methanesulfonic acid in ethanol.
参考文献标题:2-Aminoalkyl-imidazoline
文献作者:Miescher,K.; Marxer,A.; Urech,E.
参考来源:Helv Chim Acta 1950,33(5),1386-407
产品链接: CAS No. 65-28-1›› 产品链接: CAS No.50-60-2››