Nafamostat mesilate, Nafamostat mesylate, FUT-175, Futhan
甲磺酸萘莫司他萘莫司他Chemical Name: 6-Amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate; 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate
CAS No. 82956-11-4, 80251-32-7 (diHCl), 81525-10-2 (free base)
项目整合开发状态: Launched-1986
项目研究机构: Torii (Originator)
合成路线:This compound can be prepared by condensation of 4-guanidinobenzoic acid (I) with 6-amidino-2-naphthol (II) in pyridine either by means of DCC or the acid chloride of (I),(III),at room temperature.
📌 参考资料/链接：
参考文献标题:Amidine compound
文献作者:Fujii,S.; Okutome,T.; Nakayama,T.; Yaegashi,T.; Kurumi,M.(Torii Pharmaceutical Co.,Ltd.)
参考来源:JP 82179146; JP 8253454; US 4454338
📄 详细内容
合成路线:This compound can be prepared by condensation of 4-guanidinobenzoic acid (I) with 6-amidino-2-naphthol (II) in pyridine either by means of DCC or the acid chloride of (I),(III),at room temperature.
参考文献标题:Nafamstat Mesylate
文献作者:Aoyama,T.
参考来源:Drugs Fut 1984,9(10),747