Bifeprunox mesilate, DU-127090
甲磺酸联苯芦诺7-(4-(联苯-3-甲基)哌嗪-1-基)苯并[d]噁唑-2(3h)-酮Chemical Name: 7-[4-(Biphenyl-3-ylmethyl)piperazin-1-yl]benzoxazol-2(3H)-one methanesulfonate
CAS No. 350992-13-1, 362524-71-8, 350992-10-8 (free base), 197954-51-1 (hydrochloride)
项目整合开发状态: Phase III
项目研究机构: Solvay (Originator), Lundbeck (Licensee), Wyeth Pharmaceuticals (Licensee)
合成路线:The title compound was prepared by alkylation of 7-piperazinylbenzoxazol-2(3H)-one (I) with 3-phenylbenzyl bromide (II) in the presence of diisopropyl ethyl amine and KI in refluxing acetonitrile.
📌 参考资料/链接：
参考文献标题:Piperazine and piperidine cpds.
文献作者:Feenstra,R.W.; Kruse,C.G.; Tulp,M.T.M.; Kuipers,W.; Long,S.K.(Duphar International Research BV)
参考来源:JP 2000507949; US 6225312; WO 9736893
📄 详细内容
合成路线:The title compound was prepared by alkylation of 7-piperazinylbenzoxazol-2(3H)-one (I) with 3-phenylbenzyl bromide (II) in the presence of diisopropyl ethyl amine and KI in refluxing acetonitrile.
参考文献标题:New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D2-receptor and serotonin 5-HT1A-receptor affinities
文献作者:Feenstra,R.W.; de Moes,J.; Hofma,J.J.; Kling,H.; Kuipers,W.; Long,S.K.; Tulp,M.T.M.; Van der Heyden,J.A.M.; Kruse,C.G.
参考来源:Bioorg Med Chem Lett 2001,11(17),2345
产品链接: CAS No. 350992-13-1›› 产品链接: CAS No.350992-10-8››