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项目整合精选>>>Bitolterol mesylate, WIN-32784, S-1540, Asmalene, Produrol, Tornalate
Bitolterol mesylate, WIN-32784, S-1540, Asmalene, Produrol, Tornalate
甲磺酸比托特罗 比托特罗 Chemical Name: 4-Methylbenzoic acid 4-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,2-phenylene ester methanesulfonate (salt)
CAS No. 30392-41-7, 30392-40-6 (free base)
项目整合开发状态: Launched-1986
项目研究机构: Sanofi-Aventis (Originator), Elan (Not Determined)
合成路线:The reaction of 3,4-dihydroxyphenyl-tert-butylaminomethyl ketone (I) with sodium ethoxide in DMF gives the corresponding disodium salt,which without isolation is condensed with p-toluyl chloride (A) to yield 3,4-bis(p-toluyloxy)phenyl-tert-butylaminomethyl ketone hydrochloride (II); this salt is then reduced with H2 over Pd/C in ethanol or with sodium borohydride in methanol.
📌 参考资料/链接：
参考文献标题:Bitolterol
文献作者:Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1976,1(10),454
📄 详细内容
合成路线:The reaction of 3,4-dihydroxyphenyl-tert-butylaminomethyl ketone (I) with sodium ethoxide in DMF gives the corresponding disodium salt,which without isolation is condensed with p-toluyl chloride (A) to yield 3,4-bis(p-toluyloxy)phenyl-tert-butylaminomethyl ketone hydrochloride (II); this salt is then reduced with H2 over Pd/C in ethanol or with sodium borohydride in methanol.
参考文献标题:Ester von alpha-Aminomethyl-3-(hydroxy- oder hydroxymethyl)-4-hydroxybenzyl-alkoholen und Verfahren zu ihrer Herstellung
文献作者:Minatoya,H.; et al.
参考来源:DE 2015573; FR 2042295; GB 1298771
产品链接: CAS No. 30392-41-7›› 产品链接: CAS No.30392-40-6››