合成路线:The reaction of p-hydrophenylacetic acid (I) with N,N-dimethylbromoacetamide (II) by means of triethylamine in reftuxing acetonitrile gives N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate (III),which is then condensed with p-guanidinobenzoyl chloride (IV) [obtained from the corresponding acid p-guanidinobenzoic acid (V) and thionyl chloride] in pyridine.
参考文献标题:Guanidinobenzoic acid derivatives and antiplasmin agents and remedies for pancreas diseases containing the said guanidinobensolc acid derivatives
文献作者:Fujii,S.; et al.(Ono Pharmaceutical Co.,Ltd.)
参考来源:JP 52089640
合成路线:By reaction of N,N-dimethylcarbamoylmethyl-p-(p-aminobenzoyloxy)phenylacetate (VI) with cyanamide (VII).
参考文献标题:Preparation of guanidinobenzoic acid derivatives
文献作者:Fujii,S.; et al.(Ono Pharmaceutical Co.,Ltd.)
参考来源:JP 54052052
合成路线:The reaction of p-hydrophenylacetic acid (I) with N,N-dimethylbromoacetamide (II) by means of triethylamine in reftuxing acetonitrile gives N,N-dimethylcarbamoylmethyl-p-hydroxyphenylacetate (III),which is then condensed with p-guanidinobenzoyl chloride (IV) [obtained from the corresponding acid p-guanidinobenzoic acid (V) and thionyl chloride] in pyridine.
合成路线:By reaction of N,N-dimethylcarbamoylmethyl-p-(p-aminobenzoyloxy)phenylacetate (VI) with cyanamide (VII).
参考文献标题:Camostat Mesylate
文献作者:Castar,J.; Serradell,M.N.; Hashimoto,K.
参考来源:Drugs Fut 1985,10(11),897
产品链接: CAS No. 59721-29-8›› 产品链接: CAS No.59721-28-7››