Suplatast tosilate, IPD-1151T, IPD, MPD
甲磺司特Chemical Name: (?-2-[N-[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]carbamoyl]ethyldimethylsulfonium p-toluenesulfonate
CAS No. 94055-76-2
项目整合开发状态: Launched-1995
项目研究机构: Taiho (Originator), Yamanouchi (Licensee)
合成路线:The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III),which is then treated with methyl p-toluenesulfonate (IV) in dichloromethane.
📌 参考资料/链接：
参考文献标题:Sulfonium cpds.,processes for preparing the cpds.and pharmacological compsns.containing the same
文献作者:Hori,M.; Matsuura,N.; Ueda,S.; Yamawaki,I.; Yasumoto,M.; Tada,Y.; Koda,A.(Taiho Pharmaceutical Co.,Ltd.)
参考来源:CH 659066; DE 3408708; FR 2542312; GB 2137986; JP 1984167564; JP 1984170062; JP 1985152459; US 4556737
📄 详细内容
合成路线:The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III),which is then treated with methyl p-toluenesulfonate (IV) in dichloromethane.
参考文献标题:IPD-1151T
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(11),952
产品链接: CAS No. 94055-76-2››