Meteneprost, U-46785

甲烯前列素Chemical Name: 9-Deoxo-16,16-dimethyl-9-methylene-PGE2; (Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-5-methylenecyclopentyl]-5-heptenoic acid; (5Z,11alpha,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-methyleneprosta-5,13-dien-1-oic acid
CAS No. 61263-35-2
项目整合开发状态: Phase II
项目研究机构: Pfizer (Originator)
合成路线:The reaction of 16,16-dimethyl-PGE2 methyl ester bis(trimethylsilyl) ether (I) with the reaction product of N,S-dimethyl-S-phenylsulfoximine and methylmagnesium chloride (II) in THF at -78 C followed by a treatment with AlHg and acetic acid gives 9-deoxy-9-methylene-16,16-dimethyl-PGE2 methyl ester (III),which is hydrolyzed with KOH in methanol - water.