合成路线:By condensation of (-)-anhydroecgonine methyl ester (I) with 4-fluorophenylmagnesium bromide (II) by means of cuprous chloride in refluxing ether.
合成路线:The reaction of anhydroecgonine methyl ester (I) with 4-methylphenylmagnesium bromide (II) in ethyl ether gives 3beta-(4-methylphenyl)tropane-2beta-carboxylic acid methyl ester (III),which is demethylated by reaction with 2,2,2-trichloroethyl chloroformate (IV) yielding the carbamate (V),followed by reduction with Zn/AcOH to afford the nortropane derivative (VI).The alkylation of (VI) with the tributylstannane (VII),TEA and iodine in ethanol provides the adduct (VIII),which is finally brominated with NBS in THF.
参考文献标题:Compounds affecting the central nervous system.4.3beta-Phenyltropane-2-carboxylic esters and analogs
文献作者:Clarke,R.L.; Daum,S.J.; Gambino,A.J.; Aceto,M.D.; Pearl,J.; Levitt,M.; Cumiskey,W.R.; Bogado,E.F.
参考来源:J Med Chem 1973,16(1),1260-67
合成路线:By condensation of (-)-anhydroecgonine methyl ester (I) with 4-fluorophenylmagnesium bromide (II) by means of cuprous chloride in refluxing ether.
参考文献标题:
文献作者:Clarke,R.L.; Daum,S.J.
参考来源:US 3813404
产品链接: CAS No. 50370-56-4››