Recainam, Wy-42362
瑞卡南 尿素,N-(2,6-二甲基苯基)-N'-[3-[(1-甲基)氨基]丙基]-,盐酸盐(1:1) Chemical Name: N-(2,6-Dimethylphenyl)-N'-[3-(1-methylethylamino)propyl]urea; N-(2,6-Dimethylphenyl)-N'-[3-(isopropylamino)propyl]urea
CAS No. 74738-24-2, 74752-07-1 (monoHCl), 74738-32-2 (phosphate(1:1))
项目整合开发状态: Phase III
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:The reaction of p-anisaldehyde (I) with N-isopropyl-1,3-diaminopropane (II) in refluxing toluene gives N-anisylidene-N'-isopropyl-1,3-diaminopropane (III),which is then condensed with 2,6-dimethylphenylisocyanate (IV) in refluxing dichloromethane.
📌 参考资料/链接：
参考文献标题:Urea derivatives,processes for preparing them and compositions containing them
文献作者:Sulkowski,T.S.; Bergey,J.L.; Mascitti,A.A.(American Home Products Corp.)
参考来源:EP 0007184; GB 2025406; JP 80500480; US 4224242
📄 详细内容
合成路线:The reaction of p-anisaldehyde (I) with N-isopropyl-1,3-diaminopropane (II) in refluxing toluene gives N-anisylidene-N'-isopropyl-1,3-diaminopropane (III),which is then condensed with 2,6-dimethylphenylisocyanate (IV) in refluxing dichloromethane.
参考文献标题:WY-42362
文献作者:Serradell,M.N.; Castar,J.; Bad韆,A.
参考来源:Drugs Fut 1984,9(1),38
产品链接: CAS No. 74738-24-2›› 产品链接: CAS No.74752-07-1››