Regadenoson, CVT-3146
瑞加德松Chemical Name: 2-[4-(N-Methylcarbamoyl)-1H-pyrazol-4-yl)adenosine; 6-Amino-2-[4-(methylcarbamoyl)-1H-pyrazol-1-yl]purine-9-yl-beta-D-ribofuranoside
CAS No. 313348-27-5
项目整合开发状态: Phase III
项目研究机构: CV Therapeutics (Originator), Fujisawa (Licensee)
合成路线:The condensation of 2-hydrazino adenosine (I) with (ethoxycarbonyl)malondialdehyde (II) generated the pyrazole ester (III).The target amide was then obtained by displacement of the ethyl ester group of (III) with an aqueous solution of methylamine at 65 C.
📌 参考资料/链接：
参考文献标题:N-Pyrazole A2A receptor agonists
文献作者:Zablocki,J.A.; Palle,V.P.; Elzein,E.O.(CV Therapeutics,Inc.)
参考来源:EP 1189916; US 6403567; WO 0078779
📄 详细内容
合成路线:The condensation of 2-hydrazino adenosine (I) with (ethoxycarbonyl)malondialdehyde (II) generated the pyrazole ester (III).The target amide was then obtained by displacement of the ethyl ester group of (III) with an aqueous solution of methylamine at 65 C.
参考文献标题:2-Substituted pi system derivatives of adenosine that are coronary vasodilators acting via the A2A adenosine receptor
文献作者:Zablocki,J.; Palle,V.P.; Blackburn,B.K.; Elzein,E.; Nudelman,G.; Gothe,S.; Gao,Z.; Li,Z.; Meyer,S.; Belardinelli,L.
参考来源:Nucleosides Nucleotides Nucleic Acids 2001,20(4-7),343
产品链接: CAS No. 313348-27-5››