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项目整合精选>>>Cifenline succinate, Cibenzoline succinate, UP-33901(free base), Ro-227796(free base), Exacor, Cibenol, Cipralan
Cifenline succinate, Cibenzoline succinate, UP-33901(free base), Ro-227796(free base), Exacor, Cibenol, Cipralan
琥珀酸西苯唑啉 琥珀酸西苯唑啉 西苯唑啉Chemical Name: 2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole succinate
CAS No. 100678-32-8, 57625-97-5 (butanedioate (2:1)), 53267-01-9 (free base)
项目整合开发状态: Launched-1985
项目研究机构: UPSA (Originator), Beiersdorf (Licensee), Fujisawa (Licensee), Pfizer (Licensee)
合成路线:The cyclization of diphenyldiazomethane (I) with acrylonitrile (II) in CHCl3 gives cyano-2,2-diphenylcyclopropane (III),which is then cyclized with ethylenediamine tosylate (IV) by heating at 200 C.
📌 参考资料/链接：
参考文献标题:Cibenzoline
文献作者:Neuman,M.; Blancafort,P.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(4),239
📄 详细内容
合成路线:The cyclization of diphenyldiazomethane (I) with acrylonitrile (II) in CHCl3 gives cyano-2,2-diphenylcyclopropane (III),which is then cyclized with ethylenediamine tosylate (IV) by heating at 200 C.
参考文献标题:1-(2-delta(2)-Imidazolinyl)-2,2-diarylcyclopropanes and process
文献作者:Cognaco,J.-C.
参考来源:CA 1006526; CH 585207; DE 2359816; FR 2208663; GB 1417174; JP 49093363; NL 7316487; US 3903104
合成路线:The cyclization of diphenyldiazomethane (I) with acrylonitrile (II) in CHCl3 gives cyano-2,2-diphenylcyclopropane (III),which is then cyclized with ethylenediamine tosylate (IV) by heating at 200 C.
参考文献标题:Chlorinated derivatives of 1-(2-delta(2)-imidazolinyl)-2,2-diarylcyclopropanes
文献作者:Cognaco,J.-C.
参考来源:CA 1018176; CH 583200; DE 2359795; FR 2208664; JP 50004072; NL 7316484; US 3905993