合成路线:Compound can be prepared in two different ways:1) The reaction of methyl 5-oxo-5-cyclohexyl-3-methylpentenoate (I) with NH2OH gives the corresponding oxime (II),which is then cyclized to 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (III).Finally,this compound is salified with ethanolamine (IV).2) Compound (III) can also be obtained by reaction of 6-cyclohexyl-4-methyl-2-pyron (V) with hydroxylamine hydrochloride in hot 2-aminopyridine.
参考文献标题:
文献作者:Lohaus,G.; Dittmar,W.
参考来源:US 3972888
合成路线:Compound can be prepared in two different ways:1) The reaction of methyl 5-oxo-5-cyclohexyl-3-methylpentenoate (I) with NH2OH gives the corresponding oxime (II),which is then cyclized to 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (III).Finally,this compound is salified with ethanolamine (IV).2) Compound (III) can also be obtained by reaction of 6-cyclohexyl-4-methyl-2-pyron (V) with hydroxylamine hydrochloride in hot 2-aminopyridine.
参考文献标题:
文献作者:Lohaus,G.; Dittmar,W.
参考来源:ZA 6906039
合成路线:Compound can be prepared in two different ways:1) The reaction of methyl 5-oxo-5-cyclohexyl-3-methylpentenoate (I) with NH2OH gives the corresponding oxime (II),which is then cyclized to 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone (III).Finally,this compound is salified with ethanolamine (IV).2) Compound (III) can also be obtained by reaction of 6-cyclohexyl-4-methyl-2-pyron (V) with hydroxylamine hydrochloride in hot 2-aminopyridine.
参考文献标题:Ciclopirox olamine
文献作者:Blancafort,P.; Serradell,M.N.; Hopkins,S.J.; Castar,J.
参考来源:Drugs Fut 1979,4(11),795
产品链接: CAS No. 41621-49-2›› 产品链接: CAS No.29342-05-0››