网站主页>>>
项目整合精选>>>
项目整合精选>>>Ciprofibrate, Win-35833, Modalim, Hiperlipen, Lipanor, Ciprol
Ciprofibrate, Win-35833, Modalim, Hiperlipen, Lipanor, Ciprol
环丙贝特Chemical Name: 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic acid
CAS No. 52214-84-3
项目整合开发状态: Launched-1985
项目研究机构: Sanofi-Aventis (Originator)
合成路线:The Sandmeyer reaction of 4-(2',2'-dichlorocyclopropyl)aniline (I) first with NaNO2 and acetic acid and then with 33% aqueous H2SO4 at 100 C gives 4-(2',2'-dichlorocyclopropyl)phenol (II),which is then condensed with acetone (A) and CHCl3 by means of NaOH in refluxing acetone.
📌 参考资料/链接：
参考文献标题:Ciprofibrate
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1977,2(5),297
📄 详细内容
合成路线:The Sandmeyer reaction of 4-(2',2'-dichlorocyclopropyl)aniline (I) first with NaNO2 and acetic acid and then with 33% aqueous H2SO4 at 100 C gives 4-(2',2'-dichlorocyclopropyl)phenol (II),which is then condensed with acetone (A) and CHCl3 by means of NaOH in refluxing acetone.
参考文献标题:Phenoxyacetic acid and cyclopropa-alpha-naphthoxyacetic acid derivatives
文献作者:Phillips,D.K.
参考来源:DE 2343606; FR 2197586; GB 1385828; JP 58074636
产品链接: CAS No. 52214-84-3››