合成路线:By condensation of alpha,alpha-diphenyl-4-piperidinemethanol (I) with 1-(p-tert-butylphenyl)-4-chlorobutanol (II) by means of KHCO3 and KI in refluxing toluene.
合成路线:By condensation of alpha,alpha-diphenyl-4-piperidinemethanol (I) with 4'-chloro-p-tert-butyl-butyrophenone (III) by means of KHCO3 to give p-tert-butyl-4'-[4-(alpha-hydroxydiphenylmethyl)-1-piperidyl]butyrophenone (IV),which is then reduced with H2 and a catalyst.
参考文献标题:Olefinic 4-substituted piperidino deriatives
文献作者:Carr,A.A.; Kinsolving,C.R.(Aventis Pharmaceuticals,Inc.)
参考来源:ES 410732; FR 2181689; GB 1413140; JP 48085579; US 3862173
合成路线:By condensation of alpha,alpha-diphenyl-4-piperidinemethanol (I) with 1-(p-tert-butylphenyl)-4-chlorobutanol (II) by means of KHCO3 and KI in refluxing toluene.
合成路线:By condensation of alpha,alpha-diphenyl-4-piperidinemethanol (I) with 4'-chloro-p-tert-butyl-butyrophenone (III) by means of KHCO3 to give p-tert-butyl-4'-[4-(alpha-hydroxydiphenylmethyl)-1-piperidyl]butyrophenone (IV),which is then reduced with H2 and a catalyst.
参考文献标题:Terfenadine
文献作者:Thorpe,P.; Castar,J.
参考来源:Drugs Fut 1978,3(3),220
产品链接: CAS No. 50679-08-8››