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项目整合精选>>>Prednisolone sodium metasulfobenzoate, ATL-2502, Predocol, Predecol, Colal-Pred
Prednisolone sodium metasulfobenzoate, ATL-2502, Predocol, Predecol, Colal-Pred
泼尼松龙苯酰磺酸钠Chemical Name: 11beta,17-Dihydroxy-21-(3-sulfobenzoyloxy)pregna-1,4-diene-3,20-dione sodium salt; 3-Sulfobenzoic acid 21-ester with 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione monosodium salt
CAS No. 630-67-1
项目整合开发状态: Phase II
项目研究机构: Alizyme (Originator)
合成路线:Alternatively,the title compound is prepared by condensation of prednisolone 21-methanesulfonate (I) with sodium 3-sulfobenzoate (II) in DMF/H2O,followed by conversion to the corresponding sodium salt with aqueous sodium acetate.
📌 参考资料/链接：
参考文献标题:Novel process for the preparation of 21-esters of 20-keto-steroids
文献作者:Joly,R.; Warnant,J.(Aventis Pharma SA)
参考来源:FR 1344153; US 3037034
📄 详细内容
合成路线:The title compound is prepared by two alternative methods.Sulfonation of benzoic acid (I) with hot chlorosulfonic acid affords 3-carboxybenzenesulfonyl chloride (II).After conversion of (II) to the pyridine complex,coupling with prednisolone (III) produces the target 21-sulfobenzoate ester,which is finally isolated as the title sodium salt by treatment with aqueous NaOH.
参考文献标题:Process for the preparation of 21-m-sulfo benzoates of DELTA1,4-dehydrocorticosteroids
文献作者:Girault,P.; Allais,A.(Aventis Pharma SA)
参考来源:US 3032568
产品链接: CAS No. 630-67-1››