Prednisolone farnesylate, PNF-21, Farnezone, Farnerate gel
泼尼松龙法呢酯 [2-[(8S,9S,10S,11S,13S,14S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-7,8,9,11,12,14,15,16-八氢-6H-环戊二烯并[a]菲-17-基]-2-氧代-乙基]3,7,11-三甲基十二碳-2,6,10-三烯酸酯 Chemical Name: 11beta,17alpha-Dihydroxy-21-[3,7,11-trimethyl-2(E),6(E),10-dodecatrienoyloxy]pregna-1,4-diene-3,20-dione
CAS No. 118244-44-3, 118244-45-4 ((Z,Z)-isomer), 105217-71-8 (undefined isomer)
项目整合开发状态: Launched-1998
项目研究机构: Kuraray (Originator), Taiho (Originator), Dainippon Pharmaceutical (Licensee)
合成路线:By reaction of prednisolone (11beta,12alpha-dihydroxypregna-1,4-diene-3,20-dione) (I) with eitherI) 2E,6E-farnesylic acid (3,7,11-trimethyl-2(E),6(E),10-dodecatrienoic acid (II) with a suitable condensing agent (e.g.,DDC) and a disubstituted aminopyridine (e.g.,DMAP) in an organic solvent (e.g.,CH2Cl2),orII) 2E,6E-farnesylic anhydride (III) in the presence of DMAP in CH2Cl2,or withIII) 2E,6E-farnesilyl chloride (IV) in the presence of pyridine in a mixture of CH2Cl2 and THF.
📌 参考资料/链接：
参考文献标题:11beta,17alpha-Trihydroxy-1,4-pregnadiene-3,20-dione 21-[(E,E)-3,7,11-trimethyl-2,6,10-dodecatrienoate]
文献作者:Mizushima,Y.; Hoshi,K.; Igarashi,R.; Ajioka,H.; Yamamoto,N.; Komuro,M.; Kanehira,K.; Inoue,M.; Nishida,T.; Shiono,M.; Terasawa,M.; Arizono,K.(Kuraray Co.,Ltd.; Taiho Pharmaceutical Co.,Ltd.)
参考来源:EP 0332143; JP 1989316396; JP 1989316397; US 5278156
📄 详细内容
合成路线:By reaction of prednisolone (11beta,12alpha-dihydroxypregna-1,4-diene-3,20-dione) (I) with eitherI) 2E,6E-farnesylic acid (3,7,11-trimethyl-2(E),6(E),10-dodecatrienoic acid (II) with a suitable condensing agent (e.g.,DDC) and a disubstituted aminopyridine (e.g.,DMAP) in an organic solvent (e.g.,CH2Cl2),orII) 2E,6E-farnesylic anhydride (III) in the presence of DMAP in CH2Cl2,or withIII) 2E,6E-farnesilyl chloride (IV) in the presence of pyridine in a mixture of CH2Cl2 and THF.
参考文献标题:Anti-asthmatic agents
文献作者:Okada,M.; Kanehira,K.(Kuraray Co.,Ltd.; Taiho Pharmaceutical Co.,Ltd.)
参考来源:JP 1991223214
合成路线:By reaction of prednisolone (11beta,12alpha-dihydroxypregna-1,4-diene-3,20-dione) (I) with eitherI) 2E,6E-farnesylic acid (3,7,11-trimethyl-2(E),6(E),10-dodecatrienoic acid (II) with a suitable condensing agent (e.g.,DDC) and a disubstituted aminopyridine (e.g.,DMAP) in an organic solvent (e.g.,CH2Cl2),orII) 2E,6E-farnesylic anhydride (III) in the presence of DMAP in CH2Cl2,or withIII) 2E,6E-farnesilyl chloride (IV) in the presence of pyridine in a mixture of CH2Cl2 and THF.
参考文献标题:Prednisolone Farnesylate
文献作者:Castar,J.; Graul,A.; Prous,J.
参考来源:Drugs Fut 1993,18(9),805
产品链接: CAS No. 118244-44-3›› 产品链接: CAS No.118244-45-4››