Prednicarbate, S-770777, Hoe-777, Peitel, Dermatop
泼尼卡酯Chemical Name: 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 17-(ethylcarbonate) 21-propionate
CAS No. 73771-04-7
项目整合开发状态: Launched-1986
项目研究机构: Aventis Pharma (Originator), Cassella (Originator), Camillo Corvi (Licensee), Ferrer (Licensee)
合成路线:The esterification of prednisolone (I) with ethyl orthocarbonate (II) by means of p-toluenesulfonic acid in dioxane gives prednisolone 17,21-(diethylorthocarbonate) (III),which is carefully hydrolyzed with acetic acid water yielding cyclic prednisolone 17-(ethyl carbonate) (IV).Finally,this compound is esterified with propionyl chloride or propionyl anhydride in pyridine or CH2Cl2-dimethylaminopyridine,respectively.
📌 参考资料/链接：
参考文献标题:Prednicarbate
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1986,11(6),460
📄 详细内容
合成路线:The esterification of prednisolone (I) with ethyl orthocarbonate (II) by means of p-toluenesulfonic acid in dioxane gives prednisolone 17,21-(diethylorthocarbonate) (III),which is carefully hydrolyzed with acetic acid water yielding cyclic prednisolone 17-(ethyl carbonate) (IV).Finally,this compound is esterified with propionyl chloride or propionyl anhydride in pyridine or CH2Cl2-dimethylaminopyridine,respectively.
参考文献标题:Ginkgolide A,B,and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells
文献作者:Zhao,H.-W.; Li,X.-Y.
参考来源:Acta Pharm Sin 1999,20(10),941
产品链接: CAS No. 73771-04-7››