Benatoprazole, Tenatoprazole, TU-199, Ulsacare, Protop
泰妥拉唑Chemical Name: (?-5-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-ylmethylsulfinyl)imidazo[4,5-b]pyridine
CAS No. 113712-98-4
项目整合开发状态: Phase III
项目研究机构: Mitsubishi Pharma (Originator), Abbott (Licensee), Negma (Licensee)
合成路线:The condensation of 2-mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine (I) with 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine (II) by means of KOH in refluxing ethanol gives 2-(4-methoxy-3,5-dimethylpyridin-2-ylmethylthio)-5-methoxy-3H-imidazo [4,5-b]pyridine (III),which is then oxidized with m-chloroperbenzoic acid in chloroform.
📌 参考资料/链接：
参考文献标题:Imidazo[4,5-b]pyridine cpds.,process for preparing same and pharmaceutical compsns.containing same
文献作者:Matsuichi,N.; Takeda,H.; Iizumi,K.; Murakami,K.; Hisamitsu,A.(Tokyo Tanabe Co.,Ltd.)
参考来源:AU 8775628; EP 0254588; JP 1988146882
📄 详细内容
合成路线:The condensation of 2-mercapto-5-methoxy-3H-imidazo[4,5-b]pyridine (I) with 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine (II) by means of KOH in refluxing ethanol gives 2-(4-methoxy-3,5-dimethylpyridin-2-ylmethylthio)-5-methoxy-3H-imidazo [4,5-b]pyridine (III),which is then oxidized with m-chloroperbenzoic acid in chloroform.
参考文献标题:TU-199
文献作者:Mealy,N.; Castar,J.; Prous,J.
参考来源:Drugs Fut 1994,19(11),1018
产品链接: CAS No. 113712-98-4››