Ponalrestat, MK-538, ICI-128436, Prodiax, Statil
波来瑞斯Chemical Name: 3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazineacetic acid
CAS No. 72702-95-5, 72703-73-2 (Na salt)
项目整合开发状态: Phase III
项目研究机构: AstraZeneca (Originator), Banyu (Licensee)
合成路线:The condensation of ethyl 3,4-dihydro-4-oxo-phthalazine-1-acetate (I) with 4-bromo-2-fluoro benzyl bromide (II) by means of NaH in hot DMF gives ethyl 3-(4-bromo-2-fluorobenzyl)-3,4-dihydro-4-oxophthalazine-1-acetate (III),which is saponified with KOH in refluxing ethanol.
📌 参考资料/链接：
参考文献标题:Increasing vigilance or treating cerebral insuffi
文献作者:Pf鋐fli,P.(Novartis AG)
参考来源:GB 1492579; US 4146643
📄 详细内容
合成路线:The condensation of ethyl 3,4-dihydro-4-oxo-phthalazine-1-acetate (I) with 4-bromo-2-fluoro benzyl bromide (II) by means of NaH in hot DMF gives ethyl 3-(4-bromo-2-fluorobenzyl)-3,4-dihydro-4-oxophthalazine-1-acetate (III),which is saponified with KOH in refluxing ethanol.
参考文献标题:ICI-128436
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1987,12(4),347
产品链接: CAS No. 72702-95-5››