合成路线:The esterification of N-phenylanthranilic acid (I) with methanol and HCl yields the corresponding methyl ester (II),which by a Grignard reaction with methylmagnesium iodide in THF is converted into 2-anilinophenyl dimethyl carbinol (III).The cyclization of (III) with polyphosphoric acid at 170 C affords 9,9-dimethylacridan (IV),which by carbonylation with phosgene in refluxing toluene yields 9,9-dimethylacridan-10-carbonyl chloride (V) (1).Finally this compound is esterified with 2-dimethylaminoethanethiol (VI) by means of NaH in ether
参考文献标题:Synthesis of 9,9-dialkylacridans substituted at position 10
文献作者:Molnar,I.; Wagner-Jauregg,T.
参考来源:Helv Chim Acta 1965,48(7),1782
合成路线:The esterification of N-phenylanthranilic acid (I) with methanol and HCl yields the corresponding methyl ester (II),which by a Grignard reaction with methylmagnesium iodide in THF is converted into 2-anilinophenyl dimethyl carbinol (III).The cyclization of (III) with polyphosphoric acid at 170 C affords 9,9-dimethylacridan (IV),which by carbonylation with phosgene in refluxing toluene yields 9,9-dimethylacridan-10-carbonyl chloride (V) (1).Finally this compound is esterified with 2-dimethylaminoethanethiol (VI) by means of NaH in ether
参考文献标题:
文献作者:(Siegfried Aktiengesellschaft)
参考来源:DE 2161700; FR 2118100; GB 1335728
合成路线:The esterification of N-phenylanthranilic acid (I) with methanol and HCl yields the corresponding methyl ester (II),which by a Grignard reaction with methylmagnesium iodide in THF is converted into 2-anilinophenyl dimethyl carbinol (III).The cyclization of (III) with polyphosphoric acid at 170 C affords 9,9-dimethylacridan (IV),which by carbonylation with phosgene in refluxing toluene yields 9,9-dimethylacridan-10-carbonyl chloride (V) (1).Finally this compound is esterified with 2-dimethylaminoethanethiol (VI) by means of NaH in ether
参考文献标题:
文献作者:Molnar,I.; et al.(Siegfried Aktiengesellschaft)
参考来源:US 3830918
产品链接: CAS No. 4774-53-2››